新澳门葡萄京8814

院训

陈华 教授

一、个人简介

陈华, 中国科学院上海药物研究所博士 (2001-2004)。现为教授,博士研究生导师。主要从事基于糖类衍生物新药及化学生物学研究。重点开展稠杂氮杂糖、表观遗传糖修饰药物的设计合成及其抗肿瘤、抗病毒、免疫调节、酶抑制等生物活性研究,发现药物先导阐释作用机制迄今发表SCI收录论文100余篇;获授权中国发明专利 9项,先后主持国家自然科学基金、河北省自然科学基金河北省教育厅优秀青年基金项目等8项课题。

联系方式:E-mail: hua-todd@163.com

二、主讲课程及研究方向

        1. 主讲课程: 有机化学、波谱分析、有机化学实验

        2. 研究方向: 糖药物化学

三、代表性论文

1. Lianhai Yan, Hui Lui, Jiajing Sun, Ligang Gao, Xin Lu, Liping Niu, Xiaoliu Li*, Hua Chen*, Synthesis of tricyclic benzimidazole-iminosugars as potential glycosidase inhibitors via a Mitsunobu reaction, Carbohydr. Res., 2019, 485, 107807(1-8).

2. Zhe Duan, Jingqiu Liu, Liping Niu, Jun Wang, Hua Chen*, Mingqian Feng*, Cheng Luo*, Discovery of DC_H31 as potential mutant IDH1 inhibitor through NADPH-based high throughput screening, Bioorg. Med. Chem., 2019, 27(15), 3229-3236.

3. Jiajing Sun, Yaqing Kang, Ligang Gao, Xin Lu, Huanhuan Ju, Xiaoliu Li*, Hua Chen* Synthesis of tricyclic quinazolinone-iminosugars as potential glycosidase inhibitors via a Mitsunobu reaction, Carbohydr. Res., 2019, 478, 10-17.

4. Yuxin Feng, Senhao Xiao, Yantao Chen, Hao Jiang, Na Liu, Cheng Luo, Shijie Chen*, Hua Chen*, Design, synthesis and biological evaluation of benzo[cd]indol-2(1H)-ones derivatives as BRD4 inhibitors, Eur. J. Med. Chem., 2018, 128, 264-273.

5. Li Zhang, Yantao Chen, Na Liu, Linjuan Li, Senhao Xiao, Xiaoliu Li, Kaixian Chen, Cheng Luo, Shijie Chen*, Hua Chen*, Design, Synthesis and Anti Leukemia Cells Proliferation Activities of Pyrimidylaminoquinoline Derivatives as DOT1L inhibitors, Bioorg. Chem., 2018, 80, 649-654.

6. Lianhai Yan, Zhuqing Yin, Liping Niu, Jie Shao, Hua Chen*, Xiaoliu Li*, Synthesis of pentacyclic iminosugars with constrained butterfly-like conformation and their HIV-RT inhibitory activity, Bioorg. Med. Chem. Lett., 2018, 28(3), 425-428.

7. Mengying Gao, Yaxi Yang*, Hua Chen*, Bing Zhou*, Rhodium-Catalyzed C-H functionalization of indoles with diazo compounds: synthesis of structurally diverse 2,3-fused indoles, Adv. Synth. Catal., 2018, 360(1), 100-105.

8. Penglei Cui, Xiaoliu Li*, Mengyuan Zhu, Binghe Wang, Jing Liu, Hua Chen*, Design, synthesis and antimicrobial activities of thiouracil derivatives containing triazolo-thiadiazole as SecA inhibitors, Eur. J. Med. Chem., 2017, 127, 159-165.

9. Yan’en Wang, Ruixue Rong, Hua Chen*, Mengyuan Zhu, Binghe Wang*, Xiaoliu Li*, Triazole-linked fluorescent bisboronic acid capable of selective recognition of the Lewis Y antigen, Bioorg. Med. Chem. Lett., 2017, 27(8), 1983-1988.

10. Zhuqing Yin, Mo Zhu, Sinan Wei, Jie Shao, Yuheng Hou, Hua Chen*, Xiaoliu Li*, Synthesis of tetracyclic iminosugars fused benzo[e][1,3]thiazin-4-one and their HIV-RT inhibitory activity, Bioorg. Med. Chem. Lett., 2016, 26, 1738-1741.

四、科研项目

1. 新型稠杂氮杂糖类糖苷酶抑制剂的设计、合成及活性研究项目批准号: 21772031, 国家自然科学基金项目2018-2021, 主持人;

2. 新型苯并咪唑并氮杂糖的设计、合成及其糖苷酶抑制活性研究项目批准号: B2019201398, 河北省自然科学基金项目(2019-2021, 主持人;

       3. 新型稠合氮杂糖类HIV逆转录酶抑制剂的研究项目批准号: B2015201005, 河北省杰出青年科学基金培育项目2015-2017, 主持人 


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